ND building

How to find us

Notre Dame Regional High School is located on the western border of Cape Girardeau, MO. Its close proximity to I-55 allows for easier accessibility for commuting students. Notre Dame is the only Catholic high school in Southeast Missouri. 

From St. Louis

  • Take I-55 South (112 miles)
  • Take Cape exit #96 and turn right on Route K
  • Proceed 2 miles on Route K to Notre Dame Dr. on the left

From Sikeston

  • Take I-55 North (29 miles)
  • Take Cape exit #96 and turn left on Route K
  • Proceed 2 miles on Route K to Notre Dame Dr. on the left

From IL-146 W 

  • Head West on IL 146 W for 3.7 miles entering Missouri 
  • Continue on MO 74 W for 3.2 miles
  • Merge onto I 55 North (0.2 miles)
  • Take Cape exit #96 and turn left on Route K
  • Proceed 2 miles on Route K to Notre Dame Dr. on the left